CFA crews are responding to a large structure fire at the Star Entertainment Complex, corner of South Gippsland Highway and Round Tower Road in Dandenong South.
Over 50 CFA and MFB firefighters are on the scene at a restaraunt, converted from a factory, following a call at 3.42am this morning.
Firefighters have contained the fire, although a considerable amount of smoke remains in the area.
Police Victoria and Ambulance Victoria are also on the scene, however no injuries have been sustained.
A smoke warning has been issued, while one south-bound lane on the South Gippsland highway has been closed.
A roof partially collapsed at the building as a result of the fire, which began on the first floor.
Crew will remain on the scene for most of the day. The cause of the fire is unknown at this stage.