Drug companies are paying Australian doctors millions of dollars a year to fly to overseas conferences and meetings, give talks to other doctors, and to serve on advisory boards, our research shows.
Authors
Barbara Mintzes
Professor, School of Pharmacy and Charles Perkins Centre, University of Sydney
Malcolm Forbes
Consultant psychiatrist and PhD candidate, Deakin University
Our team reports from major drug companies, in the first comprehensive analysis of its kind. We found drug companies paid more than A$33 million to doctors in the three years from late 2019 to late 2022 for these consultancies and expenses.
We know this underestimates how much drug companies pay doctors as it leaves out the gift – food and drink – which drug companies in Australia do not declare.
Due to COVID restrictions, the timescale we looked at included periods where doctors were likely to be travelling less and attending fewer in-person medical conferences. So we suspect current levels of drug company funding to be even higher, especially for travel.
What we did and what we found
Since 2019, Medicines Australia, the trade association of the brand-name pharmaceutical industry, has published a centralised of payments made to individual health professionals. This is the first comprehensive analysis of this database.
We downloaded the data and matched doctors’ names with listings with the Australian Health Practitioner Regulation Agency (). We then looked at how many doctors per medical specialty received industry payments and how much companies paid to each specialty.
We found more than two-thirds of rheumatologists received industry payments. Rheumatologists often prescribe expensive new biologic drugs that suppress the immune system. These drugs are responsible for a of drug costs on the Pharmaceutical Benefits Scheme (PBS).
The specialists who received the most funding as a group were
cancer doctors (oncology/haematology specialists). They received
over $6 million in payments.
This is unsurprising given recently approved, expensive new cancer drugs. Some of these drugs are wonderful treatment advances; offer minimal improvement in survival or quality of life.
A found doctors receiving industry payments were more likely to prescribe cancer treatments of low clinical value.
Our analysis found some doctors with many small payments of a few hundred dollars. There were also instances of large individual payments.
Why does all this matter?
Doctors drug company promotion does not affect them. But research tells a different story. Industry payments both doctors’ own prescribing decisions and those of their colleagues.
A of meals provided to doctors – on average costing less than US$20 – found the more meals a doctor received, the more of the promoted drug they prescribed.
found the more meals a doctor received from manufacturers of opioids (a class of strong painkillers), the more opioids they prescribed. played a key role in the in North America.
Overall, a substantial body of research industry funding affects prescribing, for drugs that are not a first choice because of poor effectiveness, safety or cost-effectiveness.
Then there are doctors who act as “key opinion leaders” for companies. These include paid consultants who give talks to other doctors. An ex-industry employee who recruited doctors for such roles :
Key opinion leaders were salespeople for us, and we would routinely measure the return on our investment, by tracking prescriptions before and after their presentations […] If that speaker didn’t make the impact the company was looking for, then you wouldn’t invite them back.
We know about payments to US doctors
The best available evidence on the effects of pharmaceutical industry funding on prescribing comes from the US government-run program called .
Since 2013, all drug and device companies must report all payments over US$10 in value in any single year. Payment reports are linked to the promoted products, which allows researchers to compare doctors’ payments with their prescribing patterns.
Analysis of this data, which involves hundreds of thousands of doctors, has promotional payments affect prescribing.
also shows that doctors who had studied at medical schools that banned students receiving payments and gifts from drug companies were less likely to prescribe newer and more expensive drugs with limited evidence of benefit over existing drugs.
In general, Australian medical faculties have or no restrictions on medical students seeing pharmaceutical sales representatives, receiving gifts, or attending industry-sponsored events during their clinical training. They also have no restrictions on academic staff holding consultancies with manufacturers whose products they feature in their teaching.
So a first step to prevent undue pharmaceutical industry influence on prescribing decisions is to shelter medical students from this influence by having stronger conflict-of-interest policies, such as those mentioned above.
A second is better guidance for individual doctors from professional organisations and regulators on the types of funding that is and is not acceptable. We believe no doctor actively involved in patient care should accept payments from a drug company for talks, international travel or consultancies.
Third, if Medicines Australia is serious about transparency, it should require companies to list all payments – including those for food and drink – and to link health professionals’ names to their Ahpra registration numbers. This is similar to the reporting standard pharmaceutical companies follow in the US and would allow a more complete and clearer picture of what’s happening in Australia.
Patients trust doctors to choose the best available treatments to meet their health needs, based on scientific evidence of safety and effectiveness. They don’t expect marketing to influence that choice.
Barbara Mintzes is general secretary of the International Society of Independent Drug Bulletins (ISDB), a global network of bulletins and journals on drugs and therapeutics that are financially and intellectually independent of the pharmaceutical industry. The journals Australian Prescriber and Prescrire International, whose publications are cited in this article, are members of ISDB. She is also on the editorial board for Drug & Therapeutics Bulletin, and is a member of Health Action International (HAI-Europe), the Therapeutics Initiative, and of Association Mieux Prescrire. Professor Mintzes is also an expert witness for Health Canada on a legal case involving marketing of an unapproved drug product.
Malcolm Forbes receives a Psychiatric Treatment Discovery Postgraduate Research Scholarship from Deakin University and is supported by Dr Roth Trisno and family through the Trisno Family PhD Research Scholarship, awarded by the RANZCP Foundation. He has previously received funding from Avant Mutual, the Royal Australian and New Zealand College of Psychiatrists (RANZCP), and the National Health and Medical Research Council (NHMRC).
