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Documentation obtained by Animal-Free Science Advocacy (AFSA) under the Freedom of Information Act 1982 (Cth) (FOI Act) has identified an unexpected death of a macaque via strangulation, the holding of macaques significantly beyond the approved holding time, and deviations from approved protocols.

The redacted project reporting documentation relate to a project investigating viral transmission of HIV which commenced in 2018. The research was conducted by University of Melbourne researchers using 26 macaques, under the oversight of the Australian Animal Health Laboratory (AAHL) Animal Ethics Committee (AEC).

The documentation reveals that:

• 25 macaques died as part of the experimental design
• 1 macaque died from strangulation from an enrichment method
• Additional aspects were conducted without approval from the AEC
• The macaques were held longer (12 or 15 months) than the initial protocol approved due to delays in obtaining required antibodies
• Macaques were immunised with a tuberculosis vaccine without approval from the AEC
• Not all planned components of the project were completed.

There are uncertainties about what was approved versus what happened. Details are missing about the achievement of project objectives. These uncertainties come from claimed FOI Act exemptions, which have resulted in parts of the project report being redacted.

Based on the redacted documentation, it appears to AFSA that the research was not conducted in accordance with AEC approval. It is unclear to AFSA what actions were taken, if any, in relation to the apparent non-compliance, and what the consequences were, if any, of the identified errors for the research group or the AEC.

In AFSA’s view, there are clear ethical dilemmas with using animals who possess high cognitive abilities and well-developed social structures as mere ‘tools for research’, and there are scientific concerns over the validity of using primates in HIV research.