By harnessing light, my colleagues designed a wireless, ultrathin pacemaker that operates like a solar panel. This design not only eliminates the need for batteries but also minimizes disruptions to the heart’s natural function by molding to its contours. Our research, recently , offers a new approach to treatments that require electrical stimulation, such as heart pacing.
Author
Pengju Li
Ph.D. Candidate in Molecular Engineering, University of Chicago Pritzker School of Molecular Engineering
implanted in the body to regulate heart rhythms. They’re composed of electronic circuits with batteries and leads anchored to the heart muscle to stimulate it. However, leads can fail and damage tissue. The location of the leads can’t be changed once they’re implanted, limiting access to different heart regions. Because pacemakers use rigid, metallic electrodes, they may also damage tissue when or .
Our team envisioned a leadless and more flexible pacemaker that could precisely stimulate multiple areas of the heart. So we designed a device that , or heart cell-generated electrical signals. Thinner than a human hair, our pacemaker is made of an optic fiber and silicon membrane that the and colleagues at the University of Chicago have spent years developing.
Unlike that are usually designed to collect as much energy as possible, we tweaked our device to generate electricity only at points where light strikes so it can precisely regulate heartbeats. We did this by using a layer of very small pores that can trap light and electrical current. Only cardiac muscles exposed to light-activated pores are stimulated.
Because our device is so small and light, it can be implanted without opening the chest. We were able to in the hearts of rodents and an adult pig, pacing the beats of different heart muscles. Because are anatomically similar to human hearts, this accomplishment shows our device’s potential to translate to people.
Why it matters
Heart disease is the . Annually, undergo open-heart surgery to treat heart problems, including to that regulate heart rhythms and prevent heart attacks.
Our ultralight device gently conforms to the surface of the heart, enabling less invasive stimulation and improved pacing and synchronized contraction. To reduce postoperative trauma and recovery time, our device can be implanted with a minimally invasive technique.
What still isn’t known
Currently, our technology is best first used for urgent heart conditions, including restarting the heart after surgery, heart attack and ventricular defibrillation. We continue to explore its long-term effects and durability in the human body.
The body’s internal environment is that are disturbed by the heart’s constant mechanical motion. This could potentially compromise the device’s functionality over time.
Moreover, researchers don’t fully understand how the body reacts to prolonged exposure to medical devices. The formation of around the device after implantation can diminish its sensitivity. We are developing special surface treatments and biomaterial coatings to decrease the likelihood of rejection.
Although the breakdown of our device results in a nontoxic substance the body can safely absorb called , evaluating how the body responds to extended implantation is essential to ensure safety and effectiveness.
What’s next
To achieve long-term implantation and tailor the device to each patient, we are refining the rate at which it dissolves naturally in the body. We are exploring enhancements to make the device compatible as a wearable pacemaker. This involves integrating a wireless light-emitting diode, or LED, beneath the skin that is connected to the device via an optical fiber.
Our ultimate goal is to broaden the scope of what we call photoelectroceuticals beyond cardiac care. This includes , neuroprostheses and pain management to treat neurodegenerative conditions such as .
The is a short take on interesting academic work.
Pengju Li consults to the Pritzker School of Molecular Engineering. He receives funding from the University of Chicago.
