An international team of scientists has developed a groundbreaking method to measure biological ageing with unparalleled precision that has the potential to revolutionise the way we approach ageing and age-related diseases.
The research, published in , charts the development of ImAge, the first imaging-based biomarker capable of quantifying aging and rejuvenation at a single-cell level.
Study lead author postdoctoral research associate Dr Kenta Ninomiya from The University of Western Australia and the Harry Perkins Institute of Medical Research said it offered a novel approach to understanding the ageing process.
“ImAge works by analysing the spatial organisation of chromatin and epigenetic marks in individual cells,” Dr Ninomiya said.
“Unlike traditional methods that rely on chronological age, ImAge captures intrinsic age-related changes, providing a more accurate and reliable measure of biological age.
“By offering a detailed snapshot of cellular ageing, we can better understand the effects of interventions such as caloric restriction and partial reprogramming, potentially paving the way for new strategies to extend healthy lifespan.”
